Search found 10 matches
- Thu Nov 12, 2020 10:36 pm
- Forum: General Scientific Papers
- Topic: Muscimol mechanism of action
- Replies: 0
- Views: 9703
Muscimol mechanism of action
amanitadreamer I got some time to browse the literature today and have attached a PDF detailing some of the binding activity of muscimol. One quote from the paper: "Molecular modeling studies of GABA, muscimol, and bicuculline support the concept of these three agents acting at the orthosteric site...
- Sat Nov 07, 2020 2:09 pm
- Forum: Psychopharmacology and Neuroscience
- Topic: Protracted withdrawal syndrome (benzo)
- Replies: 7
- Views: 12051
Re: Protracted withdrawal syndrome (benzo)
Not sure I can give you exactly the answer you're looking for, but I can give some info and some of my experience. Muscimol is a direct GABA receptor ligand, while most of the other common chemicals (alcohol, benzos) are positive allosteric modulators. Direct receptor ligands bind to the active sit...
- Sat Nov 07, 2020 3:02 am
- Forum: Psychopharmacology and Neuroscience
- Topic: Protracted withdrawal syndrome (benzo)
- Replies: 7
- Views: 12051
Re: Protracted withdrawal syndrome (benzo)
So as for the pharmacology of kava, it is a bit of a mystery. There are probably some people who could give a better explanation than I can and there is alot of great information over at the kava forums. It is not believed to be a receptor agonizing ligand of any kind as far as I am aware. I have ta...
- Tue Nov 03, 2020 5:13 pm
- Forum: Psychopharmacology and Neuroscience
- Topic: Protracted withdrawal syndrome (benzo)
- Replies: 7
- Views: 12051
Re: Protracted withdrawal syndrome (benzo)
Not sure I can give you exactly the answer you're looking for, but I can give some info and some of my experience. Muscimol is a direct GABA receptor ligand, while most of the other common chemicals (alcohol, benzos) are positive allosteric modulators. Direct receptor ligands bind to the active site...
- Sun Oct 25, 2020 5:35 pm
- Forum: General Discussion
- Topic: alcohol 1 day prior to small Amanita dose
- Replies: 3
- Views: 2206
Re: alcohol 1 day prior to small Amanita dose
I personally don't follow that rule and have not had problems but I also can't endorse it as everyone reacts differently. I have consumed them together many times. One day apart should really not be an issue in my opinion but if you want to be as safe as possible then it won't hurt to wait.
- Thu Oct 22, 2020 7:55 pm
- Forum: General Discussion
- Topic: Let's introduce ourselves.
- Replies: 259
- Views: 1366445
Re: Let's introduce ourselves.
Hey guys, I'm a 28 year old male in northern Delaware. Have had a strange connection to Amanita muscaria for many years. I have always been very drawn to it and it is the first mushroom I ever found. I had some experiences with them in college that proved rather interesting. One of which involved an...
- Thu Oct 22, 2020 7:31 pm
- Forum: General Discussion
- Topic: Photos & Finds Thread
- Replies: 75
- Views: 402400
Re: Photos & Finds Thread
Here are a few Amanita chrysoblema (sometimes referred to as Amanita muscaria var. alba). I don't use them because white amanitas are not something I want to mess around with, but as I've found them to be fairly uncommon I took a few photos. They are definitely some cool mushrooms.
- Mon Oct 19, 2020 11:36 pm
- Forum: Preparation Methods
- Topic: Kombucha for decarboxylation? Amanita muscaria kombucha?
- Replies: 2
- Views: 9583
Kombucha for decarboxylation? Amanita muscaria kombucha?
Hi all, just wondering if anyone else uses kombucha for decarboxylation of ibotenic acid. I make my own kombucha and I tend to end up with leftover, extremely strong kombucha that is too acidic to drink for my own sensory enjoyment. I usually simmer my caps in water with a little bit of this kombuch...
- Fri Oct 16, 2020 12:44 am
- Forum: Other Amanitas
- Topic: Did I find a destroying angel?
- Replies: 9
- Views: 17957
Re: Did I find a destroying angel?
Could also be Chlorophyllum molybdites but I agree it is likely Lepiota
- Mon Oct 12, 2020 5:59 pm
- Forum: General Discussion
- Topic: Is there a scientific reason for the two-day alcohol abstinence rule?
- Replies: 19
- Views: 12819
Re: Is there a scientific reason for the two-day alcohol abstinence rule?
Not recommending that anyone else do this, but I drink an amanita tea of ~1-2 grams after drinking alcohol sometimes. I don't drink heavily, usually 3-4 drinks, but alcohol impacts my sleep in a very disruptive way and if I make a tea out of 1-2 grams of dried mushroom I sleep well through the night...