Amanita Research Forum

Abstract: To assess the influence of the γ-aminobutyric acid (GABA)A receptor on sleep and sleep EEG, rats were injected intraperitoneally with vehicle, two doses of muscimol (0.2 and 0.4 mg/kg), a selective GABAA agonist, and midazolam (3 mg/kg), a benzodiazepine-GABAA agonist. EEG and EMG recordin...

Title: The Hallucinogens Muscarine and Ibotenic Acid in the Middle Hindu Kush
A contribution on traditional medicinal mycology in Afghanistan

Link: https://www.erowid.org/plants/amanitas/ ... tan1.shtml

Yes, I've not tried any really high doses yet. I'm just curious as to what it's really 'doing' in the mind, but yes, I hear you regarding the subjective experience. Also I totally agree regarding the total removal of fear and anxiety. Even on the micro-dose level I notice that it makes me extraordin...

You're absolutely right, thanks. It's not B6 itself but pyridoxal phosphate (which is derived from B6) I'd not had a chance to look into it closely yet. The enzyme glutamic acid decarboxylase (GAD), which is found almost exclusively in GABAergic neurons, catalyzes the conversion of glutamate to GABA...

Hey all, I was just wondering what people's positions were on what is going on when one uses Amanita Muscaria? Myself I'm coming at this from the medicinal/spiritual point of view and am only micro-dosing occasionally. That said, there have been occasions when I have over stepped the mark and have h...

Title: Evidence That Wakefulness and REM Sleep Are Controlled by a GABAergic Pontine Mechanism Link: https://www.physiology.org/doi/full/10.1152/jn.1999.82.4.2015 Abstract: The pontine microinjection of the inhibitory neurotransmitter GABA and its agonist induced prolonged periods of wakefulness in ...

Title: Enzymes in Citrus Fruit, Glutamic Acid Decarboxylase of Lemons and Oranges Link: https://pubs.acs.org/doi/abs/10.1021/jf60058a009?journalCode=jafcau&fbclid=IwAR1de15d7fdVV3ExoD-MQShwp7hX08xsjQUzBEN3buO Notes: (Can't copy abstract) - Glutamic Acid Decarboxylase levels are high in lemon/orange ...

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276987/ Abstract: Rapid eye movement (REM) sleep is a behavioural state characterized by activation of the cortical and hippocampal EEG, rapid eye movements and muscle atonia. For the past 30 years, the most widely accepted neural circuitry model f...

Title: Importance of the ventrolateral region of the periaqueductal gray and adjacent tegmentum in the control of paradoxical sleep as studied by muscimol microinjections in the cat Link: https://www.sciencedirect.com/science/article/abs/pii/030645229600190X Notes: Muscimol increases REM sleep in ca...