Search found 197 matches

by Amanita Research
Sun Nov 03, 2019 9:19 pm
Forum: Scientific & Academic Papers
Topic: Role of GABA(A) Receptors in Sleep Regulation
Replies: 0
Views: 2820

Role of GABA(A) Receptors in Sleep Regulation

Abstract: To assess the influence of the γ-aminobutyric acid (GABA)A receptor on sleep and sleep EEG, rats were injected intraperitoneally with vehicle, two doses of muscimol (0.2 and 0.4 mg/kg), a selective GABAA agonist, and midazolam (3 mg/kg), a benzodiazepine-GABAA agonist. EEG and EMG recordin...
by Amanita Research
Fri Nov 01, 2019 11:27 am
Forum: General Discussion
Topic: Speculation on Amanita Muscaria's mode of action.
Replies: 2
Views: 2779

Re: Speculation on Amanita Muscaria's mode of action.

Yes, I've not tried any really high doses yet. I'm just curious as to what it's really 'doing' in the mind, but yes, I hear you regarding the subjective experience. Also I totally agree regarding the total removal of fear and anxiety. Even on the micro-dose level I notice that it makes me extraordin...
by Amanita Research
Thu Oct 31, 2019 10:48 pm
Forum: Scientific & Academic Papers
Topic: Enzymes in Citrus Fruit, Glutamic Acid Decarboxylase of Lemons and Oranges
Replies: 2
Views: 3533

Re: Enzymes in Citrus Fruit, Glutamic Acid Decarboxylase of Lemons and Oranges

You're absolutely right, thanks. It's not B6 itself but pyridoxal phosphate (which is derived from B6) I'd not had a chance to look into it closely yet. The enzyme glutamic acid decarboxylase (GAD), which is found almost exclusively in GABAergic neurons, catalyzes the conversion of glutamate to GABA...
by Amanita Research
Thu Oct 31, 2019 2:03 pm
Forum: General Discussion
Topic: Speculation on Amanita Muscaria's mode of action.
Replies: 2
Views: 2779

Speculation on Amanita Muscaria's mode of action.

Hey all, I was just wondering what people's positions were on what is going on when one uses Amanita Muscaria? Myself I'm coming at this from the medicinal/spiritual point of view and am only micro-dosing occasionally. That said, there have been occasions when I have over stepped the mark and have h...
by Amanita Research
Thu Oct 31, 2019 7:57 am
Forum: Scientific & Academic Papers
Topic: Evidence That Wakefulness and REM Sleep Are Controlled by a GABAergic Pontine Mechanism
Replies: 0
Views: 2780

Evidence That Wakefulness and REM Sleep Are Controlled by a GABAergic Pontine Mechanism

Title: Evidence That Wakefulness and REM Sleep Are Controlled by a GABAergic Pontine Mechanism Link: https://www.physiology.org/doi/full/10.1152/jn.1999.82.4.2015 Abstract: The pontine microinjection of the inhibitory neurotransmitter GABA and its agonist induced prolonged periods of wakefulness in ...
by Amanita Research
Thu Oct 31, 2019 7:51 am
Forum: Scientific & Academic Papers
Topic: Enzymes in Citrus Fruit, Glutamic Acid Decarboxylase of Lemons and Oranges
Replies: 2
Views: 3533

Enzymes in Citrus Fruit, Glutamic Acid Decarboxylase of Lemons and Oranges

Title: Enzymes in Citrus Fruit, Glutamic Acid Decarboxylase of Lemons and Oranges Link: https://pubs.acs.org/doi/abs/10.1021/jf60058a009?journalCode=jafcau&fbclid=IwAR1de15d7fdVV3ExoD-MQShwp7hX08xsjQUzBEN3buO Notes: (Can't copy abstract) - Glutamic Acid Decarboxylase levels are high in lemon/orange ...
by Amanita Research
Wed Oct 30, 2019 8:35 pm
Forum: Scientific & Academic Papers
Topic: The pontine REM switch: past and present
Replies: 0
Views: 2703

The pontine REM switch: past and present

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276987/ Abstract: Rapid eye movement (REM) sleep is a behavioural state characterized by activation of the cortical and hippocampal EEG, rapid eye movements and muscle atonia. For the past 30 years, the most widely accepted neural circuitry model f...
by Amanita Research
Wed Oct 30, 2019 8:32 pm
Forum: Scientific & Academic Papers
Topic: Importance of the ventrolateral region of the periaqueductal gray and adjacent tegmentum in the control of paradoxica...
Replies: 0
Views: 1699

Importance of the ventrolateral region of the periaqueductal gray and adjacent tegmentum in the control of paradoxica...

Title: Importance of the ventrolateral region of the periaqueductal gray and adjacent tegmentum in the control of paradoxical sleep as studied by muscimol microinjections in the cat Link: https://www.sciencedirect.com/science/article/abs/pii/030645229600190X Notes: Muscimol increases REM sleep in ca...