The Toxicological Pathologic Study of Amanita muscaria in Sprague-Dawley Rat

Papers broadly covering the Amanita genus.
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EBBII
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The Toxicological Pathologic Study of Amanita muscaria in Sprague-Dawley Rat

Post by EBBII » Thu Nov 11, 2021 11:05 am

Abstract: For the toxicological pathologic study of Amanita muscaria, we have investigated single and repeated dose toxicity in Sprague-Dawley (SD) rats. Single dose toxicity study was identified as catalepsy, incline and tail pinch methods (control 0 mg/kg, low 3.3 mg/kg, middle 16.5 mg/kg, high 33.0 mg/kg). Repeated dose toxicity study was carried out in blood tests, serum tests and histopathological methods. Neurotoxicity - muscle paralysis, and convulsion and loss of movement - was observed at 33.0 mg/kg group in the single dose toxicity study. Dysfunction of liver and kidney were shown in the repeated oral administration of the Amanita muscaria at 3-4 weeks. Serum chemistry results revealed a marked increase of LDH [Lactate Dehydrogenase (3181.5 IU/L; normal 230-460 IU/l)], ALT [Alanine transaminase (124.0 IU/l; normal.

Kim, Jin, et al. "The Toxicological Pathologic Study of Amanita muscaria in Sprague-Dawley Rat." Journal of Life Science 19.8 (2009): 1152-1158. https://www.researchgate.net/publicatio ... Dawley_Rat

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eucalyptus
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Re: The Toxicological Pathologic Study of Amanita muscaria in Sprague-Dawley Rat

Post by eucalyptus » Sun Oct 02, 2022 1:19 pm

Although the abstract is in the English, the actual study seems to be in Korean, making it difficult to read any of the data.

The abstract claims (and remember that abstracts often contradict a paper's actual data) that neurotoxicity occurred at a single dose of 33 mg/kg. For an 80 kg person this would be about 2.6 g, but we don't know of what. Fresh amanita? Dried amanita? Whole cap? Powder?

It's impossible to draw any conclusion without an English translation.

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