Amanita and how it effects diabetics

[Daltonjeff08]

Is there any information or data on how amanita effects someone with diabetes( takes insulin to) and if its safe for them to consume.

[UrsusSapiens]

Hi Daltonjeff08!
After some search, I've found only this paper:

https://diabetes.diabetesjournals.org/content/30/2/168

Abstract

This study examines the effect of muscimol, a high affinity, specific gamma-aminobutyric acid (GABA) agonist, on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas. Perfusion with low glucose (50 mg/dl) conditions resulted in basal somatostatin release of 46 ± 4 pg/ml. Basal insulin release was less than 20 μU/ml. High glucose (300 mg/dl) conditions stimulated somatostatin and insulin release. Steady-state levels of somatostatin and insulin release under high glucose conditions were 425 ± 12 pg/ml and 419 ± 18 μU/ml, respectively. Perfusion with medium containing 1 μM muscimol inhibited glucose-stimulated somatostatin release by 38%, whereas the course of glucose-stimulated insulin release was unaffected. Tentative conclusions from this study are (1) that GABA is potentially a modulator of islet somatostatin but not insulin release, and (2) the fact that somatostatin, an inhibitor of insulin, can be suppressed 38% without coincidental increase in insulin release seems to indicate that, under high glucose conditions, somatostatin is without a significant paracrine effect on the beta-cells.


Or, even shorter, -as far as rat cells can be an indicator for human cells- Muscimol is a light inhibitor for somatostatin, but does not increase itself insulin. I don't know how much and what kind of insulin you use, or how little insulin your body produces on it's own, but be sure to talk to a real M.D. for the case, that your dosage perhaps has to be reduced. But other than that, I don't see any cause, why you shouldn't microdose wit amanita muscaria.