Amanita Research Forum

Is there any information or data on how amanita effects someone with diabetes( takes insulin to) and if its safe for them to consume.

Hi Daltonjeff08!
After some search, I've found only this paper:

https://diabetes.diabetesjournals.org/content/30/2/168

Abstract

This study examines the effect of muscimol, a high affinity, specific gamma-aminobutyric acid (GABA) agonist, on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas. Perfusion with low glucose (50 mg/dl) conditions resulted in basal somatostatin release of 46 ± 4 pg/ml. Basal insulin release was less than 20 μU/ml. High glucose (300 mg/dl) conditions stimulated somatostatin and insulin release. Steady-state levels of somatostatin and insulin release under high glucose conditions were 425 ± 12 pg/ml and 419 ± 18 μU/ml, respectively. Perfusion with medium containing 1 μM muscimol inhibited glucose-stimulated somatostatin release by 38%, whereas the course of glucose-stimulated insulin release was unaffected. Tentative conclusions from this study are (1) that GABA is potentially a modulator of islet somatostatin but not insulin release, and (2) the fact that somatostatin, an inhibitor of insulin, can be suppressed 38% without coincidental increase in insulin release seems to indicate that, under high glucose conditions, somatostatin is without a significant paracrine effect on the beta-cells.


Or, even shorter, -as far as rat cells can be an indicator for human cells- Muscimol is a light inhibitor for somatostatin, but does not increase itself insulin. I don't know how much and what kind of insulin you use, or how little insulin your body produces on it's own, but be sure to talk to a real M.D. for the case, that your dosage perhaps has to be reduced. But other than that, I don't see any cause, why you shouldn't microdose wit amanita muscaria.