ADHD meds (Ritalin/Methylphenidate) and AM

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ADHD meds (Ritalin/Methylphenidate) and AM

Post by martishot » Wed Dec 15, 2021 6:17 pm

Hello all!

I've been recently diagnosed with ADHD at 30. I've been prescribed 10mg of Methylphenidate (Ritalin), and there's a chance I may move towards the longer acting version of the same compound in the near future.

Getting on these meds has been a great help in many ways.

One of the things I've been trying to find an answer on before I work with AM again is if we know whether there are any drug interactions between Methylphenidate (a CNS stimulant) and AM? If you have any sources to share that'd be very much appreciated!

As I understand the medication has a short shelf life and AM's interactions in our bodies are wide ranging. I know that Methylphenidate can't be mixed with MAO-I, which AM isn't one of those.

Any guidance is appreciate!

Kelowna, BC
On Syilx tmix'' territory

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Re: ADHD meds (Ritalin/Methylphenidate) and AM

Post by Loyo » Fri Jan 07, 2022 11:59 pm

First of all, muscimol (from amanita) and methylphenidate (for ADHD) act on NDMA and GABA receptors, so consuming both simultaneously does affect.

I personally have no experience using both at the same time, but you should be careful and try to find out more about it.

Here is some information on the long-term effect of methylphenidate on GABA and NDMA receptors: ... ne.0051910

Here is information on how muscimol can prevent neurotoxicity associated with NDMA by activating GABA receptors:

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