Effects of Amanita muscaria extract on different in vitro neurotoxicity models at sub-cellular and cellular levels.

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Effects of Amanita muscaria extract on different in vitro neurotoxicity models at sub-cellular and cellular levels.

Post by Amanita Research » Tue Oct 01, 2019 8:57 pm

https://www.ncbi.nlm.nih.gov/pubmed/313 ... 5dM1jl_80E

Abstract: Muscimol is the main compound found in Amanita muscaria. Several studies have proven that muscimol has suppressive effects on essential tremor, without impairing speech and coordination. The effects of muscimol in Parkinson-affected patients is also described in a number of studies. These studies describe the free radical scavenging and antioxidant activity of the mushroom extract. We have evaluated the possible neuroprotective effects of a standardized extract from A. muscaria, containing high amounts of muscimol, on different models of neurotoxicity in rat brain microsomes, mitochondria, synaptosomes as well as on neuroblastoma cell line SH-SY5Y. The possible inhibitory effect on human recombinant monoaminoxidase-B (hMAOB) enzyme was also studied. The extract revealed statistically significant neuroprotective effects on the in vitro neurotoxicity models and no inhibitory activity on hMAOB.

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Re: Effects of Amanita muscaria extract on different in vitro neurotoxicity models at sub-cellular and cellular levels.

Post by clwnthr » Mon Sep 21, 2020 7:42 am

Here's the full study. Good one.

https://sci-hub.tw/10.1016/j.fct.2019.110687

"The results of the current study will serve as an initial step in revealing the potential use of Amanita muscaria, as possible and perspective source of valuable antioxidants, neuroprotectors and as additional therapy of neurodegenerative diseases."

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