Long-term behavioral, electrophysiological, and neurochemical monitoring of the safety of an experimental antiepilept...

Post by **Amanita Research** » Sun Oct 20, 2019 9:28 pm

Title: Long-term behavioral, electrophysiological, and neurochemical monitoring of the safety of an experimental antiepileptic implant, the muscimol-delivering Subdural Pharmacotherapy Device in monkeys

Link: https://thejns.org/view/journals/j-neur ... e-p162.xml

Abstract: (Results Section)
The SPD was well tolerated in all monkeys for up to 11 months. The behavioral study revealed that during both saline and muscimol SPD treatment, the monkeys could achieve the maximum motor performance of 40 food-pellet removals per session, as before surgery. The EEG study showed that local EEG power spectra were not affected by muscimol treatment with SPD. The neurochemical study demonstrated that the administration of 1.0 mM muscimol into the neocortical subarachnoid space led to no detectable levels of this compound in the blood and cisternal CSF, as measured 1–125 minutes after delivery. Total protein levels were within the normal range in the cisternal CSF, but protein levels in the cortical-site CSF were significantly higher than normal: 361 ± 81.6 mg/dl. Abrupt discontinuation of 3-month, periodic, subdural muscimol treatments induced withdrawal seizures, which could be completely prevented by gradually tapering off the subdural muscimol concentration from 1.0 mM to 0.12–0.03 mM over a period of 2 weeks. The monkeys' general health and weight were maintained. Infection occurred only in one monkey 9 months after surgery.

Notes: Emphasis mine. May suggest an addictive potential for long term muscimol use. Would perhaps be similar to Benzo withdrawal symptoms if so. (Speculation). https://en.wikipedia.org/wiki/Benzodiaz ... #Mechanism