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Enzymes in Citrus Fruit, Glutamic Acid Decarboxylase of Lemons and Oranges
Posted: Thu Oct 31, 2019 7:51 am
by Amanita Research
Title: Enzymes in Citrus Fruit, Glutamic Acid Decarboxylase of Lemons and Oranges
Link:
https://pubs.acs.org/doi/abs/10.1021/jf ... QUzBEN3buO
Notes: (Can't copy abstract) - Glutamic Acid Decarboxylase levels are high in lemon/orange juice. This is speculated by us, not paper, to break down Ibotenic acid to muscimol also as it is the enzyme that converts glutamic acid to GABA.
Re: Enzymes in Citrus Fruit, Glutamic Acid Decarboxylase of Lemons and Oranges
Posted: Thu Oct 31, 2019 8:38 pm
by RBG
Can't GAD only convert glutamate if there's vitamin B6 present? I don't think citrus has much vitamin b.
Re: Enzymes in Citrus Fruit, Glutamic Acid Decarboxylase of Lemons and Oranges
Posted: Thu Oct 31, 2019 10:48 pm
by Amanita Research
You're absolutely right, thanks. It's not B6 itself but pyridoxal phosphate (which is derived from B6) I'd not had a chance to look into it closely yet.
The enzyme glutamic acid decarboxylase (GAD), which is found almost exclusively in GABAergic neurons, catalyzes the conversion of glutamate to GABA (Figure 6.10A). GAD requires a cofactor, pyridoxal phosphate, for activity. Because pyridoxal phosphate is derived from vitamin B6, a B6 deficiency can lead to diminished GABA synthesis. The significance of this became clear after a disastrous series of infant deaths was linked to the omission of vitamin B6 from infant formula. The lack of B6 resulted in a large reduction in the GABA content of the brain, and the subsequent loss of synaptic inhibition caused seizures that in some cases were fatal.
From
here.