The effect of muscimol on prolactin secretion in male rats

A place to share academic research on Amantias.
Post Reply
User avatar
Amanita Research
Site Admin
Posts: 197
Joined: Tue Oct 01, 2019 7:44 pm
Has thanked: 143 times
Been thanked: 106 times

The effect of muscimol on prolactin secretion in male rats

Post by Amanita Research » Tue Oct 01, 2019 10:04 pm

https://www.scholars.northwestern.edu/e ... WDgxo7PKWM

Abstract: In order to further clarify the conflicting reports on the effect of gamma-aminobutyric acid (GABA) on prolactin (PRL) secretion, we have examined the effect of a potent, centrally active GABA receptor agonist, muscimol, on basal and pharmacologically elevated plasma PRL levels in male rats. Intravenous administration of muscimol, in doses from 0.5-5.0 mg/kg, produced no change in resting plasma PRL levels 15 and 30 minutes after its administration. In animals pretreated with alphamethylparatyrosine (100 mg/kg, intraperitoneally), muscimol (0.1-1.0 mg/kg, i.v.) produced significant decreases in plasma PRL concentrations. Muscimol, (5.0 mg/kg, i.p.) also significantly inhibited PRL secretion in rats pretreated with haloperidol (1.0 mg/kg, i.p.). This effect of muscimol is probably due to its ability to activate central GABA receptors.

odonamon
Posts: 5
Joined: Wed Dec 11, 2019 2:03 am
Has thanked: 1 time
Been thanked: 1 time

Re: The effect of muscimol on prolactin secretion in male rats

Post by odonamon » Sat Dec 14, 2019 6:14 pm

Interesting. I would read this as Amanita having a neutral effect on libido ‘bounce back’.

Any other takes on these findings?

Post Reply