Re-examining the Role of Muscarine in the Chemistry of Amanita muscaria
Posted: Tue Oct 27, 2020 12:23 am
Re-examining the Role of Muscarine in the Chemistry of Amanita muscaria
The chemistry of the Amanita muscaria mushroom has long been a puzzle for scientists, and many pieces of this puzzle remain in dispute. One recurrent dispute centers on the role of muscarine in Amanita muscaria inebriations and poisonings. Currently, it is widely (and mistakenly) believed that muscarine does not occur in Amanita muscaria in pharmacologically active levels. While muscarine is unable to cross the blood-brain barrier, and contributes no psychoactive effects to Amanita muscaria inebriation, the evidence presented herein suggests that muscarine is present in sufficient quantities to have a physiological effect when moderate amounts of this mushroom are consumed. Failing to recognize the physiological contribution of muscarine to the Amanita muscaria experience leaves us with an incomplete picture of the properties of this mushroom and how it was perceived by the cultures who revered it.
Link: https://www.researchgate.net/publicatio ... a_muscaria
The chemistry of the Amanita muscaria mushroom has long been a puzzle for scientists, and many pieces of this puzzle remain in dispute. One recurrent dispute centers on the role of muscarine in Amanita muscaria inebriations and poisonings. Currently, it is widely (and mistakenly) believed that muscarine does not occur in Amanita muscaria in pharmacologically active levels. While muscarine is unable to cross the blood-brain barrier, and contributes no psychoactive effects to Amanita muscaria inebriation, the evidence presented herein suggests that muscarine is present in sufficient quantities to have a physiological effect when moderate amounts of this mushroom are consumed. Failing to recognize the physiological contribution of muscarine to the Amanita muscaria experience leaves us with an incomplete picture of the properties of this mushroom and how it was perceived by the cultures who revered it.
Link: https://www.researchgate.net/publicatio ... a_muscaria