Abstract: For the toxicological pathologic study of Amanita muscaria, we have investigated single and repeated dose toxicity in Sprague-Dawley (SD) rats. Single dose toxicity study was identified as catalepsy, incline and tail pinch methods (control 0 mg/kg, low 3.3 mg/kg, middle 16.5 mg/kg, high 33.0 mg/kg). Repeated dose toxicity study was carried out in blood tests, serum tests and histopathological methods. Neurotoxicity - muscle paralysis, and convulsion and loss of movement - was observed at 33.0 mg/kg group in the single dose toxicity study. Dysfunction of liver and kidney were shown in the repeated oral administration of the Amanita muscaria at 3-4 weeks. Serum chemistry results revealed a marked increase of LDH [Lactate Dehydrogenase (3181.5 IU/L; normal 230-460 IU/l)], ALT [Alanine transaminase (124.0 IU/l; normal.
Kim, Jin, et al. "The Toxicological Pathologic Study of Amanita muscaria in Sprague-Dawley Rat." Journal of Life Science 19.8 (2009): 1152-1158. https://www.researchgate.net/publicatio ... Dawley_Rat
Papers broadly covering the Amanita genus.
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